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bioRxiv · 10.1101/2023.05.20.541588

Human co-ripples facilitate neuronal interactions between cortical locations.

Verzhbinsky, I. A.·Rubin, D. B.·Kajfez, S.·Bu, Y.·Hochberg, L. R.·Cash, S. S.·Halgren, E.
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Abstract

Synchronous bursts of high frequency oscillations ( ripples) are hypothesized to contribute to binding by facilitating integration of neuronal firing across cortical locations. We tested this hypothesis using local field-potentials and single-unit firing from four 96-channel microelectrode arrays in supragranular cortex of 3 patients. Neurons in co-rippling locations showed increased short-latency co-firing, prediction of each-others firing, and co-participation in neural assemblies. Effects were similar for putative pyramidal and interneurons, during NREM sleep and waking, in temporal and Rolandic cortices, and at distances up to 16mm. Increased co-prediction during co-ripples was maintained when firing-rate changes were equated, and were strongly modulated by ripple phase. Co-ripple enhanced prediction is reciprocal, synergistic with local upstates, and further enhanced when multiple sites co-ripple. Together, these results support the hypothesis that trans-cortical co-ripples increase the integration of neuronal firing of neurons in different cortical locations, and do so in part through phase-modulation rather than unstructured activation.

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Verzhbinsky, I. A., Rubin, D. B., Kajfez, S., Bu, Y., Hochberg, L. R., Cash, S. S., Halgren, E.. 2023-05-22. Human co-ripples facilitate neuronal interactions between cortical locations.. https://doi.org/10.1101/2023.05.20.541588

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