Motor adaptation is facilitated by sleep-associated modulation of beta oscillations

Abstract

Motor adaptation reflects the ability of the brains sensorimotor system to flexibly deal with environmental changes to generate effective motor behaviour. Whether sleep contributes to the consolidation of motor adaptation remains controversial. In this study, we investigated the impact of sleep on motor adaptation and its neurophysiological correlates in a novel motor adaptation task that leverages a highly automatized motor skill, i.e., typing. We hypothesized that sleep-associated memory consolidation would benefit motor adaptation and induce modulations in task-related beta band (13-30Hz) activity during adaptation. Healthy young male experts in typing on the regular computer keyboard were trained to type on a vertically mirrored keyboard while brain activity was recorded using electroencephalography (EEG). Typing performance was assessed either after a full night of sleep with polysomnography or a similar period of daytime wakefulness. Results showed improved motor adaptation performance after nocturnal sleep but not after daytime wakefulness, and decreased beta power (a) during mirrored typing as compared to regular typing, and (b) in the post-sleep vs. the pre-sleep mirrored typing sessions. Furthermore, the slope of the EEG signal, a measure of aperiodic brain activity, decreased during mirrored as compared to regular typing. Changes in the EEG spectral slope from pre- to post-sleep mirrored typing sessions were correlated with changes in task performance. Finally, increased fast sleep spindle density (13-15Hz) during the night following motor adaptation training was predictive of successful motor adaptation. These findings suggest that post-training sleep modulates neural activity mechanisms supporting adaptive motor functions.