Reduced frequency of clonal hematopoiesis in Parkinson's disease

Sun, S.; Sproviero, D.; Payan-Gomez, C.; Huang, Z.; Hoeijmakers, J. H. J.; Maslov, A. Y.; Mastroberardino, P. G.; Vijg, J.

doi:10.1101/2023.05.04.539397

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bioRxiv · 10.1101/2023.05.04.539397

Reduced frequency of clonal hematopoiesis in Parkinson's disease

Sun, S.·Sproviero, D.·Payan-Gomez, C.·Huang, Z.·Hoeijmakers, J. H. J.·Maslov, A. Y.·Mastroberardino, P. G.·Vijg, J.

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Abstract

To test if clonal hematopoiesis of indeterminate potential (CHIP) is associated with the incidence of Parkinsons Disease (PD), we analyzed blood whole exome sequencing data from 171 healthy controls and 335 PD subjects in the Parkinsons Progression Markers Initiative. We observed an age-related increase of CHIP carriers in the healthy controls. Surprisingly, the percentage of CHIP carriers was significantly lower in old PD patients than in age-matched controls.

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Sun, S., Sproviero, D., Payan-Gomez, C., Huang, Z., Hoeijmakers, J. H. J., Maslov, A. Y., Mastroberardino, P. G., Vijg, J.. 2023-05-07. Reduced frequency of clonal hematopoiesis in Parkinson's disease. https://doi.org/10.1101/2023.05.04.539397

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