Sperm Toolbox - A selection of small molecules to study human spermatozoa

Gruber, F. S.; Richardson, A.; Johnston, Z. C.; Myles, R.; Norcross, N.; Day, D.; Georgiou, I.; Sesma Sanz, L.; Wilson, C.; Read, K. D.; Martins da Silva, S.; Barratt, C. L.; Gilbert, I. H.; Swedlow, J. R.

doi:10.1101/2023.05.02.539126

bioRxiv · 10.1101/2023.05.02.539126

Sperm Toolbox - A selection of small molecules to study human spermatozoa

Gruber, F. S.·Richardson, A.·Johnston, Z. C.·Myles, R.·Norcross, N.·Day, D.·Georgiou, I.·Sesma Sanz, L.·Wilson, C.·Read, K. D.·Martins da Silva, S.·Barratt, C. L.·Gilbert, I. H.·Swedlow, J. R.

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Abstract

Male contraceptive options and infertility treatments are limited. To help overcome these limitations we established a small molecule library as a toolbox for assay development and screening campaigns using human spermatozoa. We have profiled all compounds in our automated high-throughput screening platform and provide the dataset, which allows direct side-by-side comparisons of compound effects and assays using live human spermatozoa.

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Gruber, F. S., Richardson, A., Johnston, Z. C., Myles, R., Norcross, N., Day, D., Georgiou, I., Sesma Sanz, L., Wilson, C., Read, K. D., Martins da Silva, S., Barratt, C. L., Gilbert, I. H., Swedlow, J. R.. 2023-05-02. Sperm Toolbox - A selection of small molecules to study human spermatozoa. https://doi.org/10.1101/2023.05.02.539126

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