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bioRxiv · 10.1101/2023.04.26.538380

Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs

Han, F.·Mu, C. M.·Bian, K.·Mu, Z.·Duan, Q.·Guo, J. Y.·Ma, J.·Jin, L.·Liu, W.·Chen, F.
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Abstract

Malignant ascites in hepatocellular carcinoma is usually a sign of advanced disease and poor prognosis and is also thought to be associated with chronic inflammation mediated by neutrophil extracellular trap networks (NETs). Whereas ozone, a strong oxidant, has significant antibacterial and anti-inflammatory effects, its effectiveness in treating malignant liver ascites is unclear.cOzone showed significant anti-peritoneal fluid production properties in H22 tumor-bearing mice, and ozone reduced peritoneal fluid production by activating AMPK and up-regulating SR-A phagocytosis damage-associated molecular patterns (DAMPs) to reduce the production of NETs. This suggests that ozone could be used as a new drug for the treatment of malignant ascites in hepatocellular carcinoma.

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Han, F., Mu, C. M., Bian, K., Mu, Z., Duan, Q., Guo, J. Y., Ma, J., Jin, L., Liu, W., Chen, F.. 2023-04-29. Mechanism of ozone alleviation of malignant ascites in hepatocellular carcinoma through inhibition of NETs. https://doi.org/10.1101/2023.04.26.538380

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