Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task

Paparella, I.; Campbell, I.; Sharifpour, R.; Beckers, E.; Berger, A.; Balda Aizpurua, J. F.; Koshmanova, E.; Mortazavi, N.; Talwar, P.; Degueldre, C.; Lamalle, L.; Sherif, S.; Phillips, C.; Maquet, P.; Vandewalle, G.

doi:10.1101/2023.04.15.536992

bioRxiv · 10.1101/2023.04.15.536992

Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task

Paparella, I.·Campbell, I.·Sharifpour, R.·Beckers, E.·Berger, A.·Balda Aizpurua, J. F.·Koshmanova, E.·Mortazavi, N.·Talwar, P.·Degueldre, C.·Lamalle, L.·Sherif, S.·Phillips, C.·Maquet, P.·Vandewalle, G.

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Abstract

Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to trigger this stimulating effect is not established. We recorded the brain activity of 19 healthy young participants (24.05{+/-}2.63; 12 women) while they completed an auditory attentional task in darkness or under an active (blue-enriched) or a control (orange) light, in an ultra-high-field 7 Tesla MRI scanner. We tested if light modulated the effective connectivity between an area of the posterior associative thalamus, encompassing the pulvinar, and the intraparietal sulcus (IPS), key areas in the regulation of attention. We found that only the blue-enriched light strengthened the connection from the posterior thalamus to the IPS. Our results provide the first empirical data supporting that blue wavelength light affects ongoing non-visual cognitive activity by modulating task-dependent information flow from subcortical to cortical areas.

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Paparella, I., Campbell, I., Sharifpour, R., Beckers, E., Berger, A., Balda Aizpurua, J. F., Koshmanova, E., Mortazavi, N., Talwar, P., Degueldre, C., Lamalle, L., Sherif, S., Phillips, C., Maquet, P., Vandewalle, G.. 2023-04-15. Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task. https://doi.org/10.1101/2023.04.15.536992

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