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bioRxiv · 10.1101/2023.04.12.536421

Understanding the link between functional profiles and intelligence through dimensionality reduction and graph analysis

Abstract

There is a growing interest in neuroscience for how individual-specific structural and functional features of the cortex relate to cognitive traits. This work builds on previous research which, using classical high-dimensional approaches, has proven that the interindividual variability of functional connectivity profiles reflects differences in fluid intelligence. To provide an additional perspective into this relationship, the present study uses a recent framework for investigating cortical organization: functional gradients. This approach places local connectivity profiles within a common low-dimensional space whose axes are functionally interretable dimensions. Specifically, this study uses a data-driven approach focussing on areas where FC variability is highest across individuals to model different facets of intelligence. For one of these loci, in the right ventral-lateral prefrontal cortex (vlPFC), we describe an association between fluid intelligence and relative functional distance from sensory and high-cognition systems. Furthermore, the topological properties of this region indicate that with decreasing functional affinity with the latter, its functional connections are more evenly distributed across all networks. Participating in multiple functional networks may reflect a better ability to coordinate sensory and high-order cognitive systems. Significant StatementThe human brain is highly variable. In particular, the way brain regions communicate to one another - that is, how they are functionally connected - constitutes a neural fingerprint of the individual. In this study, we make use of a recent methodological approach to characterize the connectivity patterns of transmodal (closely linked to abstract processing) and unimodal (closely linked to sensory processing) brain regions in an attempt to explain how this balance affects intelligence. We show that the more the functional profile of executive control regions is distant to that of abstract processing, the better they are at integrating information coming from widespread neural systems, ultimately leading to better cognitive performance.

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BibTeXRIS

Alberti, F., Menardi, A., Margulies, D. S., Vallesi, A.. 2023-04-12. Understanding the link between functional profiles and intelligence through dimensionality reduction and graph analysis. https://doi.org/10.1101/2023.04.12.536421

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