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bioRxiv · 10.1101/2023.04.11.535671

Molecular profiling of high-level athlete skeletal muscle after acute exercise - a systems biology approach

Abstract

Life-long high-level exercise training leads to improvements in physical performance and multi-tissue adaptation following changes in molecular pathways. While skeletal muscle baseline differences between exercise-trained and untrained individuals have been previously investigated, it remains unclear how acute exercise multi-omics are influenced by training history. We recruited and extensively characterized 24 individuals categorized as endurance athletes, strength athletes or control subjects. Multi-omics profiling was performed from skeletal muscle before and at three time-points after endurance or resistance exercise sessions. Timeseries multi-omics analysis revealed distinct differences in molecular processes such as fatty- and amino acid metabolism and for transcription factors such as HIF1A and the MYF-family between both exercise history and acute form of exercise. Furthermore, we found a "transcriptional specialization effect" by transcriptional narrowing and intensification. Finally, we performed multi-omics network analysis and clustering, providing a novel resource of skeletal muscle transcriptomic and metabolomic profiling in highly trained and untrained individuals.

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Reitzner, S. M., Emanuelsson, E. B., Arif, M., Kaczkowski, B., Kwon, A. T.-J., Mardinoglu, A., Arner, E., Chapman, M. A., Sundberg, C. J.. 2023-04-11. Molecular profiling of high-level athlete skeletal muscle after acute exercise - a systems biology approach. https://doi.org/10.1101/2023.04.11.535671

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