Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system

Peh, A.; Dinakis, E.; Nakai, M.; Muralitharan, R. R.; Rupasinghe, S.; Wilson, J. L.; Wong, C. H. Y.; Jama, H.; Barker, C. M. O.; Modarresi, M.; Kemp-Harper, B. K.; Zheng, T.; Marques, F. Z.; Broughton, B. R. S.

doi:10.1101/2023.04.03.535309

bioRxiv · 10.1101/2023.04.03.535309

Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system

Peh, A.·Dinakis, E.·Nakai, M.·Muralitharan, R. R.·Rupasinghe, S.·Wilson, J. L.·Wong, C. H. Y.·Jama, H.·Barker, C. M. O.·Modarresi, M.·Kemp-Harper, B. K.·Zheng, T.·Marques, F. Z.·Broughton, B. R. S.

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Abstract

We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate that the activation of the sympathetic nervous system after stroke promotes gut-derived bacteria to enter to the brain, and this process worsens motor function in mice. Abstract Figure O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=106 SRC="FIGDIR/small/535309v1_ufig1.gif" ALT="Figure 1"> View larger version (32K): org.highwire.dtl.DTLVardef@1e78ca0org.highwire.dtl.DTLVardef@c1886forg.highwire.dtl.DTLVardef@1e45ae1org.highwire.dtl.DTLVardef@10aa224_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Peh, A., Dinakis, E., Nakai, M., Muralitharan, R. R., Rupasinghe, S., Wilson, J. L., Wong, C. H. Y., Jama, H., Barker, C. M. O., Modarresi, M., Kemp-Harper, B. K., Zheng, T., Marques, F. Z., Broughton, B. R. S.. 2023-04-03. Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system. https://doi.org/10.1101/2023.04.03.535309

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