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bioRxiv · 10.1101/2023.03.23.533976

Modeling, dissecting, and subtyping of E-Cadherin inactivation-associated diffuse-type gastric adenocarcinoma

Zou, G.·Huang, Y.·Zhang, S.·Ko, K.-P.·Kim, B. J.·Zhang, J.·Pizzi, M. P.·Jun, S.·Niu, N.·Wang, H.·Song, S.·Ajani, J. A.·Park, J.-I.
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Abstract

This study investigates diffuse-type gastric adenocarcinoma (DGAC), a deadly and treatment-resistant cancer. It reveals that CDH1 inactivation occurs in a subset of DGAC patient tumors, leading to the identification of two distinct DGAC subtypes. The findings emphasize the importance of understanding DGACs molecular diversity for personalized medicine in patients with CDH1 inactivation.

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Zou, G., Huang, Y., Zhang, S., Ko, K.-P., Kim, B. J., Zhang, J., Pizzi, M. P., Jun, S., Niu, N., Wang, H., Song, S., Ajani, J. A., Park, J.-I.. 2023-03-25. Modeling, dissecting, and subtyping of E-Cadherin inactivation-associated diffuse-type gastric adenocarcinoma. https://doi.org/10.1101/2023.03.23.533976

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