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bioRxiv · 10.1101/2023.03.21.533605

An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line

Görtler, F.·Al-Roshdi, M.·Grellscheid, S. N.·Stevenson, T.
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Abstract

Senescent cells are characterized by an arrest in proliferation. In addition to replicative senescence resulting from telomere exhaustion, sub-lethal genotoxic stress resulting from DNA damage, oncogene activation, mitochondrial dysfunction or reactive metabolites also elicits a senescence phenotype. Senescence is a controlled programme affecting a wide variety of biological processes with some core hallmarks of senescence as well as tissue specific changes. This study presents an integrative multi-omic analysis of proteomic and RNA-seq from proliferating and senescent osteosarcoma cells. This study demonstrates senescence induction in a widely used cell line which can be used as a model system for characterising cancer cell responses to sub-lethal doses of chemotherapeutic agents, and makes available both RNA-seq and proteomic data from proliferating and senescent cells in open access repositories to aid reuse by the community.

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Görtler, F., Al-Roshdi, M., Grellscheid, S. N., Stevenson, T.. 2023-03-21. An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line. https://doi.org/10.1101/2023.03.21.533605

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