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bioRxiv · 10.1101/2023.03.15.532611

The structure and function of neural connectomes are shaped by a small number of design principles

Abstract

The map of synaptic connectivity among neurons in the brain shapes the computations that neural circuits may perform. Inferring the design principles of neural connectomes is, therefore, fundamental for understanding brain development and architecture, neural computations, learning, and behavior. Here, we learn probabilistic generative models for the connectomes of the olfactory bulb of zebrafish, part of the mouse visual cortex, and of C. elegans. We show that, in all cases, models that rely on a surprisingly small number of simple biological and physical features are highly accurate in replicating a wide range of properties of the measured circuits. Specifically, they accurately predict the existence of individual synapses and their strength, distributions of synaptic indegree and outdegree of the neurons, frequency of sub-network motifs, and more. Furthermore, we simulate synthetic circuits generated by our model for the olfactory bulb of zebrafish and show that they replicate the computation that the real circuit performs in response to olfactory cues. Finally, we show that specific failures of our models reflect missing design features that we uncover by adding latent features to the model. Thus, our results reflect surprisingly simple design principles of real connectomes in three different systems and species, and offer a novel general computational framework for analyzing connectomes and linking structure and function in neural circuits.

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BibTeXRIS

Haber, A., Wanner, A., Friedrich, R. W., Schneidman, E.. 2023-03-15. The structure and function of neural connectomes are shaped by a small number of design principles. https://doi.org/10.1101/2023.03.15.532611

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