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bioRxiv · 10.1101/2023.03.10.532084

The Drug Repurposing Encyclopedia (DRE): a web server for systematic drug repurposing across 20 organisms

Li, X.·Sanchez-Burgos, L.·Huhn, D.·Fernandez-Capetillo, O.
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Abstract

The identification of new therapeutic uses for compounds via computational or experimental approaches, which is widely known as drug repurposing, has the potential to develop novel therapies with pre-existing medicines, thereby reducing the time and costs associated with drug development. Today, several data-driven methodologies have been developed leading to databases that facilitate drug repurposing initiatives. However, no approach has systematically compared drug transcriptional profiles to those from a wide spectrum of human diseases or molecular pathways. Here, we present the Drug Repurposing Encyclopedia (DRE, https://www.drugrep.org), an interactive web server covering over 198M significant drug-signature associations across 20 organisms to allow users to carry out drug-repositioning analyses. DRE consists of 12 modules covering real-time drug-repurposing for user-provided transcriptional signatures; gene set enrichment analysis (GSEA) for all available drug transcriptomics profiles; as well as similarity analyses for provided gene sets across all database signatures. Collectively, DRE provides a one-stop comprehensive solution to help scientists interested in drug-repurposing studies.

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Li, X., Sanchez-Burgos, L., Huhn, D., Fernandez-Capetillo, O.. 2023-03-12. The Drug Repurposing Encyclopedia (DRE): a web server for systematic drug repurposing across 20 organisms. https://doi.org/10.1101/2023.03.10.532084

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