Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death

Jain, A.; Gosling, J.; Liu, S.; Wang, H.; Stone, E.; Perez Garcia, L.; Amabilino, D. B.; Fromhold, T. M.; Smith, S.; Rahman, R.; Long, Y.; Turyanska, L.; Rawson, F.

doi:10.1101/2023.03.02.529075

bioRxiv · 10.1101/2023.03.02.529075

Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death

Jain, A.·Gosling, J.·Liu, S.·Wang, H.·Stone, E.·Perez Garcia, L.·Amabilino, D. B.·Fromhold, T. M.·Smith, S.·Rahman, R.·Long, Y.·Turyanska, L.·Rawson, F.

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Abstract

Quantum biological tunnelling for electron transfer (QBET) is involved in controlling cellular behaviour. Control of electrical-molecular communication could revolutionise the development of disruptive technologies for understanding and modulating electrically induced molecular signalling. Current communication technology is not appropriate for interfacing with cells at a spatial/temporal level equivalent to the native biological signalling. This limits our ability to tune cell function by controlling single molecular events. Here, we merge wireless nano-electrochemical tools with cancer cells. Gold-bipolar nanoelectrodes functionalised with redox active species were developed as electric field stimulated bio-actuators, that we term bio-nanoantennae. We show that a remote electrical input regulates electron transport between the redox molecules on the bio-nanoantennae in a selective manner. The wireless modulation of electron transport results in QBET triggering apoptosis in patient-derived cancer cells, representing electrical-induced induced controlled molecular signalling. Transcriptomics data highlight the electric field-induced nanoantenna targets the cancer cells in a unique manner. The insight concerning action and functional nanomaterials opens a plethora of applications in healthcare. This approach may lead to new quantum-based medical diagnostics and treatments, as well as a fundamental understanding of biological physics.

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Jain, A., Gosling, J., Liu, S., Wang, H., Stone, E., Perez Garcia, L., Amabilino, D. B., Fromhold, T. M., Smith, S., Rahman, R., Long, Y., Turyanska, L., Rawson, F.. 2023-03-02. Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death. https://doi.org/10.1101/2023.03.02.529075

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