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bioRxiv · 10.1101/2023.02.28.530490

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies

Gao, S. M.·Qi, Y.·Zhang, Q.·Mohammed, A. S.·Lee, Y.-T.·Guan, Y.·Li, H.·Fu, Y.·Wang, M. C.
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Abstract

Organism aging occurs at the multicellular level; however, how pro-longevity mechanisms slow down aging in different cell types remains unclear. We generated single-cell transcriptomic atlases across the lifespan of Caenorhabditis elegans under different pro-longevity conditions (http://mengwanglab.org/atlas). We found cell-specific, age-related changes across somatic and germ cell types and developed transcriptomic aging clocks for different tissues. These clocks enabled us to determine tissue-specific aging-slowing effects of different pro-longevity mechanisms, and identify major cell types sensitive to these regulations. Additionally, we provided a systemic view of alternative polyadenylation events in different cell types, as well as their cell-type-specific changes during aging and under different pro-longevity conditions. Together, this study provides molecular insights into how aging occurs in different cell types and how they respond to pro-longevity strategies.

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Gao, S. M., Qi, Y., Zhang, Q., Mohammed, A. S., Lee, Y.-T., Guan, Y., Li, H., Fu, Y., Wang, M. C.. 2023-03-01. Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies. https://doi.org/10.1101/2023.02.28.530490

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