Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Abbott, K. L.; Ali, A.; Casalena, D.; Do, B. T.; Ferreira, R.; Cheah, J. H.; Soule, C. K.; Deik, A.; Kunchok, T.; Schmidt, D. R.; Renner, S.; Honeder, S. E.; Wu, M.; Chan, S. H.; Tseyang, T.; Greaves, D.; Hsu, P. P.; Ng, C. W.; Zhang, C. J.; Farsidjani, A.; Gramatikov, I. M. T.; Matheson, N. J.; Lewis, C. A.; Clish, C. B.; Rees, M. G.; Roth, J. A.; Griner, L. M.; Muir, A.; Auld, D. S.; Vander Heiden, M. G.

doi:10.1101/2023.02.25.529972

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bioRxiv · 10.1101/2023.02.25.529972

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

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INTRODUCTION INTRODUCTION RESULTS DISCUSSION KEY RESOURCES TABLE CONTACT FOR REAGENT AND... EXPERIMENTAL MODEL AND SUBJECT... METHOD DETAILS QUANTIFICATION AND STATISTICAL... Data resources DATA AND SOFTWARE AVAILABILITY AUTHOR CONTRIBUTIONS DECLARATION OF INTERESTS REFERENCES Studies of cancer cells in standard culture conditions have long been used as a tractable tool for drug discovery. Cell culture provides unparalleled experimental flexibility, scalability, and low cost to identify and understand the response to cancer therapeutics; however, drug responses in culture are not always predictive of drug response in animal models or in patients1 ...

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Abbott, K. L., Ali, A., Casalena, D., Do, B. T., Ferreira, R., Cheah, J. H., Soule, C. K., Deik, A., Kunchok, T., Schmidt, D. R., Renner, S., Honeder, S. E., Wu, M., Chan, S. H., Tseyang, T., Greaves, D., Hsu, P. P., Ng, C. W., Zhang, C. J., Farsidjani, A., Gramatikov, I. M. T., Matheson, N. J., Lewis, C. A., Clish, C. B., Rees, M. G., Roth, J. A., Griner, L. M., Muir, A., Auld, D. S., Vander Heiden, M. G.. 2023-02-27. Screening in serum-derived medium reveals differential response to compounds targeting metabolism. https://doi.org/10.1101/2023.02.25.529972

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