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bioRxiv · 10.1101/2023.02.23.529684

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

Waschke, L.·Kamp, F.·van den Elzen, E.·Krishna, S.·Lindenberger, U.·Rutishauser, U.·Garrett, D. D.
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Abstract

During memory formation, the hippocampus is presumed to represent the "content" of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

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Waschke, L., Kamp, F., van den Elzen, E., Krishna, S., Lindenberger, U., Rutishauser, U., Garrett, D. D.. 2023-02-23. Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. https://doi.org/10.1101/2023.02.23.529684

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