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bioRxiv · 10.1101/2023.02.09.527783

Stochastic Modeling of Tinnitus Loudness

Kwak, S.·Lee, D.·Jang, S.·Kim, S.·Doo, W.·Kwak, E.
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Abstract

There has been no study on the relationship between chronic tinnitus and harmonic templates. Harmonic templates are harmonically structured receptive fields in the auditory system in which all frequency components are integer multiples of a common fundamental frequency (F0). In this study, data from 19 harmonic templates from each of 196 chronic tinnitus patients were analyzed and mathematical modeling was performed to quantify the loudness of chronic tinnitus. High-resolution hearing threshold data were obtained by algorithmic pure tone audiometry (PTA) conducting automated PTA at 134 frequency bands with 1/24 octave resolution from 250 Hz to 12,000 Hz. The result showed that there is an intriguing relationship between the auditory instability of harmonic templates and simplified tinnitus severity score (STSS). This study provides several mathematical models to estimate tinnitus severity and the precise quantification of the loudness of chronic tinnitus. Our computational models and analysis of the behavioral hearing threshold fine structure suggest that the cause of severe chronic tinnitus could be a severe disparity between different temporal capacities of each neural oscillator in a certain harmonic template.

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Kwak, S., Lee, D., Jang, S., Kim, S., Doo, W., Kwak, E.. 2023-02-10. Stochastic Modeling of Tinnitus Loudness. https://doi.org/10.1101/2023.02.09.527783

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