Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal

Kudtarkar, P.; Costanzo, M.; Sun, Y.; Jang, D.; Koesterer, R.; Mychaleckyj, J. C.; Nayak, U.; Onengut-Gumuscu, S.; Rich, S. S.; Flannick, J. A.; Gaulton, K. J.; Burtt, N. P.

doi:10.1101/2023.02.03.526066

bioRxiv · 10.1101/2023.02.03.526066

Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal

Kudtarkar, P.·Costanzo, M.·Sun, Y.·Jang, D.·Koesterer, R.·Mychaleckyj, J. C.·Nayak, U.·Onengut-Gumuscu, S.·Rich, S. S.·Flannick, J. A.·Gaulton, K. J.·Burtt, N. P.

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Abstract

Translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight can reveal novel biology and therapeutic targets but remains a major challenge. We developed the T1D Knowledge Portal (T1DKP), a disease-specific resource of genetic and functional annotation data that enables users to develop hypotheses for T1D-based research and target discovery. The T1DKP can be used to query genes and genomic regions for genetic associations, identify epigenomic features, access results of bioinformatic analyses, and obtain expert-curated resources. The T1DKP is available at http://t1d.hugeamp.org.

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Kudtarkar, P., Costanzo, M., Sun, Y., Jang, D., Koesterer, R., Mychaleckyj, J. C., Nayak, U., Onengut-Gumuscu, S., Rich, S. S., Flannick, J. A., Gaulton, K. J., Burtt, N. P.. 2023-02-05. Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal. https://doi.org/10.1101/2023.02.03.526066

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