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bioRxiv · 10.1101/2023.01.19.524817

Structure of sleep explained by wave mechanics

Kharchenko, V. A.·Zhdanova, I.
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Abstract

Explaining the complex structure and dynamics of sleep, which consist of alternating and physiologically distinct NonREM and REM sleep episodes, has posed a significant challenge. In this study, we demonstrate that a single wave model concept captures the distinctly different overnight dynamics of the four primary sleep measures - the duration and intensity of NonREM and REM sleep episodes - with high quantitative precision. Additionally, the model accurately predicts how these measures respond to sleep deprivation or abundance. Furthermore, the model passes the ultimate test, as its prediction leads to a novel experimental finding--an invariant relationship between the duration of NonREM episodes and the intensity of REM episodes, the product of which remains constant over consecutive sleep cycles. These results suggest a functional unity between NonREM and REM sleep, establishing a comprehensive and quantitative framework for understanding normal sleep and sleep disorders.

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Kharchenko, V. A., Zhdanova, I.. 2023-01-20. Structure of sleep explained by wave mechanics. https://doi.org/10.1101/2023.01.19.524817

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