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bioRxiv · 10.1101/2023.01.13.523934

Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex

Abstract

Recent theories of cortical organisation maintain that important features of brain function emerge through the spatial arrangement of regions of cortex. For example, areas of association cortex are located in regions of cortex furthest from sensory and motor cortex. Association cortex is also interdigitated since adjacent regions can have relatively different patterns of functional connectivity. It is assumed that topographic properties such as distance between cortical regions constrain their functions. For example, large distances between association and sensory and motor systems may enable these areas of cortex to maintain differentiable neural patterns, while an interdigitated organisation may enable association cortex to contain many functional systems in a relatively compact space. We currently lack a formal understanding of how spatial organisation impacts brain function, limiting the ability to leverage cortical topography to facilitate better interpretations of a regions function. Here we use variograms, a quantification of spatial autocorrelation, to develop a cortex-wide profile of how functional similarity changes as a function of the distance between regions. We establish that function changes gradually within sensory and motor cortex as the distance between regions increases, while in association cortex function changes rapidly over shorter distances. Subsequent analysis suggests these differential classes of spatial dependency are related to variation in intracortical myelin between sensory motor and association cortex. Our study suggests primary and association cortex are differentiated by the degree to which function varies over space, emphasising the need to formally account for spatial properties when estimating a systems contribution to cognition and behaviour. Significance statementThe spatial arrangements of regions in the human brain are hypothesised to underpin important features of a brain regions function. Currently, however, we lack a formal understanding of how topography shapes brain function, limiting our ability to leverage topographical perspectives to inform better theories of brain function. Here we use a formal mathematical approach to establish that in regions of association cortex function varies across the cortex more rapidly than in sensory and motor cortex, a phenomenon linked to levels of intracortical myelin. This result highlights how topographical features distinguish between cortical regions with different functional profiles and provides a formal account of how spatial differences support different features of brain function.

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BibTeXRIS

Leech, R., Vos de Wael, R., Vasa, F., Xu, T., Benn, R. A. B., Scholz, R., Braga, R., Milham, M., Royer, J., Bernhardt, B., Jones, E. J., Jefferies, E., Margulies, D. S., Smallwood, J.. 2023-01-13. Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex. https://doi.org/10.1101/2023.01.13.523934

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