Order of events in a developing genetic code

Yarus, M.

doi:10.1101/2022.12.31.522385

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bioRxiv · 10.1101/2022.12.31.522385

Order of events in a developing genetic code

Yarus, M.

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Abstract

Preexisting partial genetic codes can fuse to evolve toward the Standard Genetic Code (SGC). Code fusion provides a path of least selection, generating a code precursor that resembles the SGC, consequently evolving quickly. Optimal evolution requires wobble coding delayed until late in primordial codon assignment, because early wobble specifically retards evolution of complete and accurate codes. Given delayed wobble, the SGC can emerge after a modest selection for more proficient encoding.

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Yarus, M.. 2023-01-02. Order of events in a developing genetic code. https://doi.org/10.1101/2022.12.31.522385

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