Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Renz, P. V.; Surbek, D.; Haesler, V.; Tscherrig, V.; Huang, E. J.; Chavali, M.; Liddelow, S. A.; Rowitch, D.; Schoeberlein, A.; Brosius Lutz, A. R.

doi:10.1101/2022.12.19.521083

bioRxiv · 10.1101/2022.12.19.521083

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Renz, P. V.·Surbek, D.·Haesler, V.·Tscherrig, V.·Huang, E. J.·Chavali, M.·Liddelow, S. A.·Rowitch, D.·Schoeberlein, A.·Brosius Lutz, A. R.

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Abstract

The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing the formation of a C3-expressing neuroinflammatory reactive astrocyte sub-state rescues myelination and behavioral deficits. We further demonstrate the presence of C3-expressing reactive astrocytes in human WMI. Our data point to these cells as putative drivers of myelination failure in WMI and a potentially promising therapeutic target.

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Renz, P. V., Surbek, D., Haesler, V., Tscherrig, V., Huang, E. J., Chavali, M., Liddelow, S. A., Rowitch, D., Schoeberlein, A., Brosius Lutz, A. R.. 2022-12-20. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury. https://doi.org/10.1101/2022.12.19.521083

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