Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

Mantell, K. E.; Shirinpour, S.; Puonti, O.; Xu, T.; Zimmermann, J.; Heilbronner, S. R.; Thielscher, A.; Opitz, A.

doi:10.1101/2022.12.05.519206

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bioRxiv · 10.1101/2022.12.05.519206

Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

Mantell, K. E.·Shirinpour, S.·Puonti, O.·Xu, T.·Zimmermann, J.·Heilbronner, S. R.·Thielscher, A.·Opitz, A.

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Abstract

Non-human primates (NHPs) have become key for translational research in noninvasive brain stimulation (NIBS). However, in order to create comparable stimulation conditions to humans it is vital to evaluate and match electric fields across species. Numerical models to simulate electric fields are an important tool for experimental planning in NHPs and translation to human studies. It is thus essential to evaluate how anatomical details in NHP models affect NIBS electric fields. Here, we create a highly accurate head model of a non-human primate (NHP) from 10.5 T MR data. We systematically evaluate how muscle tissue and head size (due to different MRI fields of view) affect simulation results in transcranial electric and magnetic stimulation (TES and TMS). Our findings indicate that the inclusion of muscle can affect TES electric field strength up to 29.5% while TMS is largely unaffected. Additionally, comparing a full head model to a cropped head model illustrates the impact of head size on electric fields for both TES and TMS. We find opposing effects between TES and TMS with an increase up to 13.5% for TES and a decrease up to 21.5% for TMS for the cropped head model compared to the full head model. Our results provide important insights into the level of anatomical detail needed for NHP head models and can inform future translational efforts for NIBS studies. HighlightsO_LIWe created a high resolution non-human primate FEM head model from 10.5 T MR data. C_LIO_LIWe ran transcranial electric and magnetic stimulation (TES and TMS) simulations to evaluate the effects of muscle and head size on the induced electric field in the brain. C_LIO_LIWe simulated both isotropic and anisotropic muscle conductivities. C_LIO_LIMuscle tissue can greatly affect simulation results for TES (increase electric field strength by up to 29.5%), but not for TMS. C_LIO_LIThere are opposing, but large effects of using a full head model versus a cropped head model for both TES (increase up to 13.5%) and TMS (decrease of up to 21.5%) C_LI

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Mantell, K. E., Shirinpour, S., Puonti, O., Xu, T., Zimmermann, J., Heilbronner, S. R., Thielscher, A., Opitz, A.. 2022-12-06. Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model. https://doi.org/10.1101/2022.12.05.519206

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