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bioRxiv · 10.1101/2022.12.05.519148

Non-invasive multi-channel electrophysiology of the human spinal cord - assessing somatosensory processing from periphery to cortex

Abstract

The spinal cord is of fundamental importance for integrative processing in brain-body communication, yet routine non-invasive recordings in humans are hindered by vast methodological challenges. Here we overcome these challenges by developing an easy-to-use electrophysiological approach based on high-density multi-channel spinal recordings combined with multivariate spatial-filtering analyses. These advances enable a spatiotemporal characterization of spinal cord responses and demonstrate a sensitivity that permits assessing even single-trial responses. To furthermore enable the study of integrative processing along the neural processing hierarchy in somatosensation, we expand this approach by simultaneous peripheral, spinal and cortical recordings and provide direct evidence that bottom-up integrative processing occurs already within the spinal cord and thus after the first synaptic relay in the central nervous system. Finally, we demonstrate the versatility of this approach by providing non-invasive recordings of nociceptive spinal cord responses during heat-pain stimulation. Beyond establishing a new window on human spinal cord function at millisecond timescale, this work provides the foundation to study brain-body communication in its entirety in health and disease.

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BibTeXRIS

Nierula, B., Stephani, T., Kaptan, M., Mouraux, A., Maess, B., Villringer, A., Curio, G., Nikulin, V. V., Eippert, F.. 2022-12-05. Non-invasive multi-channel electrophysiology of the human spinal cord - assessing somatosensory processing from periphery to cortex. https://doi.org/10.1101/2022.12.05.519148

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