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bioRxiv · 10.1101/2022.11.09.515792

The effects of gamma-aminobutyric acid (GABA) on working memory and attention: A randomized, double-blind, placebo-controlled, crossover trial

Altinok, A.·Karabay, A.·de Jong, J.·Balta, G.·Akyurek, E. G.
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Abstract

Background{gamma}-aminobutyric acid (GABA) is a primary inhibitory neurotransmitter that plays a significant role in the central nervous system. Studies on both animals and humans show it has the pharmacological potential for reducing the impact of cognitive disorders, as well as enhancing cognitive functions and mood. However, its specific effects on human attention and working memory have not yet been extensively studied. AimsIn this randomised, double-blind, placebo-controlled, and crossover trial, we aimed to test whether the administration of 800 mg GABA, dissolved in a drink, acutely affected visual working memory maintenance, as well as temporal and spatial attention in healthy adults. MethodsThe participants were 32 young adults (16 females and 16 males). Working memory recall precision, spatial attention and temporal attention were measured by a delayed match-to-sample task, a visual search task, and a speeded rapid serial visual presentation task, respectively. Participants completed two experimental sessions (GABA and Placebo) in randomized and counterbalanced order. In each session, forty-five minutes after administration of the drink, they completed the all three of the aforementioned cognitive tasks. ResultsLinear mixed model analysis results showed that GABA increased visual search time, compared to the placebo, but did not affect visual search accuracy, temporal attention, nor visual working memory precision. ConclusionsThe results suggest that GABA increases visual search time but does not affect temporal attention and memory, and that previously reported effects on cognition might rely on other functions.

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Altinok, A., Karabay, A., de Jong, J., Balta, G., Akyurek, E. G.. 2022-11-09. The effects of gamma-aminobutyric acid (GABA) on working memory and attention: A randomized, double-blind, placebo-controlled, crossover trial. https://doi.org/10.1101/2022.11.09.515792

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