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bioRxiv · 10.1101/2022.10.24.513503

Episodic long-term memory formation during slow-wave sleep

Schmidig, F. J.·Ruch, S.·Henke, K.
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Abstract

We are unresponsive during slow-wave sleep but continue monitoring external events for survival. Our brain wakens us when danger is imminent. If events are non-threatening, our brain might store them for later consideration to improve decision-making. To test this hypothesis, we examined whether novel vocabulary consisting of simultaneously played pseudowords and translation words are encoded/stored during sleep, and which neural-electrical events facilitate encoding/storage. An algorithm for brain-state dependent stimulation selectively targeted word pairs to slow-wave peaks or troughs. Retrieval tests were given 12 and 36 hours later. These tests required decisions regarding the semantic category of previously sleep-played pseudowords. The sleep-played vocabulary influenced awake decision-making 36 hours later, if targeted to troughs. The words linguistic processing raised neural complexity. The words semantic-associative encoding was supported by increased theta power during the ensuing peak. Fast-spindle power ramped up during a second peak likely aiding consolidation. Hence, new vocabulary played during slow-wave sleep was stored and influenced decision-making days later.

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Schmidig, F. J., Ruch, S., Henke, K.. 2022-10-25. Episodic long-term memory formation during slow-wave sleep. https://doi.org/10.1101/2022.10.24.513503

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