What is hidden in the darkness? Characterization of AlphaFold structural space.

Durairaj, J.; Pereira, J.; Akdel, M.; Schwede, T.

doi:10.1101/2022.10.11.511548

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bioRxiv · 10.1101/2022.10.11.511548

What is hidden in the darkness? Characterization of AlphaFold structural space.

Durairaj, J.·Pereira, J.·Akdel, M.·Schwede, T.

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Abstract

The recent public release of the latest version of the AlphaFold database has given us access to over 200 million predicted protein structures. We use a "shape-mer" approach, a structural fragmentation method analogous to sequence k-mers, to describe these structures and look for novelties - both in terms of proteins with rare or novel structural composition and possible functional annotation of under-studied proteins. Data and code will be made available at https://github.com/TurtleTools/afdb-shapemer-darkness

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Durairaj, J., Pereira, J., Akdel, M., Schwede, T.. 2022-10-13. What is hidden in the darkness? Characterization of AlphaFold structural space.. https://doi.org/10.1101/2022.10.11.511548

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