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bioRxiv · 10.1101/2022.09.30.510404

Pneumatic Controlled Nano-Sieve for Efficient Capture and Release of Nanoparticles

Nanaware, A.·Kranbuhl, T.·Ching, J.·Chen, J. S.·Chen, X.·Tu, H.·Du, K.
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Abstract

A pneumatic controlled nano-sieve device is demonstrated for the efficient capture and release of 15 nm quantum dots. This device consists of a 200 nm deep glass channel and a PDMS-based pneumatic pressure layer to enhance target capture. The fluid motion inside the nano-sieve is studied by computational fluidic dynamics (CFD) and microfluidic experiments, enabling efficient target capture with a flow rate as high as 100 L/min. In addition, micro-grooves are fabricated inside the nano-sieve to create low flow rate regions, which further improves the target capture efficiency. A velocity contour plot is constructed with CFD, revealing the flow rate is lowest at the top and bottom of the micro-grooves. This phenomenon is supported by the observed nanoparticle clusters surrounding the micro-grooves. By changing the morphology and pneumatic pressure, this device will also facilitate rapid capture and release of various biomolecules.

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Nanaware, A., Kranbuhl, T., Ching, J., Chen, J. S., Chen, X., Tu, H., Du, K.. 2022-10-03. Pneumatic Controlled Nano-Sieve for Efficient Capture and Release of Nanoparticles. https://doi.org/10.1101/2022.09.30.510404

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