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bioRxiv · 10.1101/2022.09.26.508537

A conserved role for stomatin domain genes in olfactory behavior

Abstract

The highly-conserved stomatin domain has been identified in genes throughout all classes of life. In animals, different stomatin domain-encoding genes have been implicated in the function of the kidney, red blood cells, and specific neuron types, though the underlying mechanisms remain unresolved. In one well-studied example of stomatin domain gene function, the C. elegans gene mec-2 and its mouse homologue Stoml3 are required for the function of mechanosensory neurons, where they modulate the activity of mechanosensory ion channels on the plasma membrane. Here we identify an additional shared function for mec-2 and Stoml3 in a very different sensory context, that of olfaction. In worms, we find that a subset of stomatin domain genes are expressed in olfactory neurons, but only mec-2 is strongly required for olfactory behavior. mec-2 acts cell-autonomously and does not have any observable effect on olfactory neuron development or morphology, but modestly reduces olfactory neuron activity. We generate a Stoml3 knockout mouse and demonstrate that, like its worm homologue mec-2, it is required for olfactory behavior. In mice, Stoml3 is not required for odor detection, but is required for odor discrimination. Therefore, in addition to their shared roles in mechanosensory behavior, mec-2 and Stoml3 also have a shared role in olfactory behavior.

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BibTeXRIS

Liang, X., Taylor, M., Napier-Jameson, R., Calovich-Benne, C., Norris, A. D.. 2022-09-27. A conserved role for stomatin domain genes in olfactory behavior. https://doi.org/10.1101/2022.09.26.508537

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