A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets

Creason, A. L.; Watson, C.; Gu, Q.; Persson, D.; Sargent, L. L.; Chen, Y.-A.; Lin, J.-R.; Sivagnanam, S.; Wünnemann, F.; Nirmal, A. J.; Chin, K.; Feiler, H. S.; Coussens, L. M.; Schapiro, D.; Grüning, B. A.; Sorger, P. K.; Sokolov, A.; Goecks, J.

doi:10.1101/2022.08.18.504436

bioRxiv · 10.1101/2022.08.18.504436

A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets

Creason, A. L.·Watson, C.·Gu, Q.·Persson, D.·Sargent, L. L.·Chen, Y.-A.·Lin, J.-R.·Sivagnanam, S.·Wünnemann, F.·Nirmal, A. J.·Chin, K.·Feiler, H. S.·Coussens, L. M.·Schapiro, D.·Grüning, B. A.·Sorger, P. K.·Sokolov, A.·Goecks, J.

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Abstract

Highly multiplexed tissue imaging (MTI) are powerful spatial proteomics technologies that enable in situ single-cell characterization of tissues. However, analysis and visualization of MTI datasets remains challenging, and we developed the Galaxy-ME software hub to address this challenge. Galaxy-ME is a web-based, interactive software hub that enables end-to-end analysis and visualization of MTI datasets and is accessible to everyone. To demonstrate its utility, Galaxy-ME was used to analyze datasets obtained from multiple MTI assays in both normal and cancerous tissues. Galaxy-ME is a publicly available web resource.

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Creason, A. L., Watson, C., Gu, Q., Persson, D., Sargent, L. L., Chen, Y.-A., Lin, J.-R., Sivagnanam, S., Wünnemann, F., Nirmal, A. J., Chin, K., Feiler, H. S., Coussens, L. M., Schapiro, D., Grüning, B. A., Sorger, P. K., Sokolov, A., Goecks, J.. 2022-08-19. A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets. https://doi.org/10.1101/2022.08.18.504436

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