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bioRxiv · 10.1101/2022.08.05.502961

AlphaPulldown - a Python package for protein-protein interaction screens using AlphaFold-Multimer

Yu, D.·Chojnowski, G.·Rosenthal, M.·Kosinski, J.
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Abstract

SummaryThe Artificial Intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions. Here, we present AlphaPulldown, a Python package that streamlines protein-protein interaction screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command line interface, a variety of confidence scores, and a graphical analysis tool. Availability and implementationAlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown.

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Yu, D., Chojnowski, G., Rosenthal, M., Kosinski, J.. 2022-08-06. AlphaPulldown - a Python package for protein-protein interaction screens using AlphaFold-Multimer. https://doi.org/10.1101/2022.08.05.502961

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