Cancer prevalence is remarkably low in turtles and is correlated with life history traits in birds, mammals, and squamates

Bulls, S.; Platner, L.; Ayub, W.; Moreno, N.; Arditi, J.-P.; McCain, S.; Wagner, P.; Bruins - van Sonsbeek, L. G. R.; Lynch, V. J.; Claude, J.; Glaberman, S.; Chiari, Y.

doi:10.1101/2022.07.12.499088

bioRxiv · 10.1101/2022.07.12.499088

Cancer prevalence is remarkably low in turtles and is correlated with life history traits in birds, mammals, and squamates

Bulls, S.·Platner, L.·Ayub, W.·Moreno, N.·Arditi, J.-P.·McCain, S.·Wagner, P.·Bruins - van Sonsbeek, L. G. R.·Lynch, V. J.·Claude, J.·Glaberman, S.·Chiari, Y.

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Abstract

Identifying species with unusually low cancer prevalence can provide new insights into cancer resistance. Most studies have focused on mammals, but the genetic, physiological, and ecological diversity among vertebrates can influence cancer susceptibility. We used necropsies from over a thousand species of amphibians, birds, crocodilians, mammals, squamates, and turtles to investigate relationships between cancer prevalence, intrinsic cancer risk, body mass, and lifespan. Previous studies often relied on species averages, leading to inaccurate interpretations. Our innovative statistical approach uses raw cancer data and resampling to improve accuracy. We found remarkably low cancer prevalence in turtles, high prevalence in squamates and mammals, and lower-than-expected prevalence based on lifespan and body mass in multiple groups. Our results show lifespan influences neoplasia and malignancy transformation rates in mammals, while body mass affects neoplasia prevalence in amphibians and squamates. These data reveal a complex relationship between life history traits and cancer risk, identifying vertebrates with potential novel cancer resistance mechanisms. STATEMENT OF SIGNIFICANCEBiodiversity is an untapped natural resource for understanding cancer. Our study reveals a wide divergence in cancer prevalence among vertebrate groups, with notably low rates in turtles and high rates in squamates and mammals. These findings can lead to new breakthroughs in understanding the biology of cancer.

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Bulls, S., Platner, L., Ayub, W., Moreno, N., Arditi, J.-P., McCain, S., Wagner, P., Bruins - van Sonsbeek, L. G. R., Lynch, V. J., Claude, J., Glaberman, S., Chiari, Y.. 2022-07-14. Cancer prevalence is remarkably low in turtles and is correlated with life history traits in birds, mammals, and squamates. https://doi.org/10.1101/2022.07.12.499088

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