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bioRxiv · 10.1101/2022.06.30.498337

Interactive analysis of functional residues in protein families

Price, M. N.·Arkin, A. P.
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Abstract

A proteins function depends on functional residues that determine its binding specificity or its catalytic activity, but these residues are typically not considered when annotating a proteins function. To help biologists investigate the functional residues of proteins, we developed two interactive web-based tools, SitesBLAST and Sites on a Tree. Given a protein sequence, SitesBLAST finds homologs that have known functional residues and shows whether the functional residues are conserved. Sites on a Tree shows how functional residues vary across a protein family by showing them on a phylogenetic tree. These tools are available at http://papers.genomics.lbl.gov/sites.

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Price, M. N., Arkin, A. P.. 2022-07-02. Interactive analysis of functional residues in protein families. https://doi.org/10.1101/2022.06.30.498337

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