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bioRxiv · 10.1101/2022.06.28.497955

Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson's disease

Bahners, B. H.·Spooner, R. K.·Hartmann, C. J.·Schnitzler, A.·Florin, E.
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Abstract

Subthalamic deep brain stimulation is effective in alleviating motor symptoms in Parkinsons disease. Establishing the clinically best stimulation settings often requires time-consuming test sessions and creates a need for biomarkers to optimize this process. While stimulation-evoked cortical responses have been proposed as such a neurophysiological marker, their relationship to motor performance has not yet been studied systematically. For this aim, we recorded finger-tapping movements and cortical responses evoked by different stimulation amplitudes of 22 patients with Parkinsons disease using magnetoencephalography. The motor cortex amplitude was a significant predictor of a higher finger tap frequency and a more regular tapping profile. In addition, subthalamic stimulation evoked responses in the inferior and middle frontal gyrus, and the supplementary motor area. While earlier studies relied on a limited cortical coverage, we reveal a cortical distribution of responses that aligns with the basal ganglia-thalamo-cortical network. Our study sheds light on the relationship between cortical responses evoked by subthalamic stimulation and motor performance based on objective quantitative parameters. Stimulation-evoked responses could guide clinical programming in the future.

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Bahners, B. H., Spooner, R. K., Hartmann, C. J., Schnitzler, A., Florin, E.. 2022-07-03. Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson's disease. https://doi.org/10.1101/2022.06.28.497955

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