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bioRxiv · 10.1101/2022.06.28.497929

Peptide from NSP7 is able to form amyloid-like fibrils: artifact or challenge to drug design?

Garmay, Y. P.·Rubel, A. A.·Egorov, V. V.
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Abstract

Using a set of programs for analyzing the primary structure of amyloidogenic proteins, we analyzed the primary structure of the of the COVID-19 NSP7 protein. Peptides containing potential amyloidogenic determinants in the primary structure have been synthesized and shown to be capable of forming amyloid-like fibrils in vitro. In the future, this peptide can be used as a basis for creating antiviral agents that act directly on the spatial structure of the NSP7 subunit of the COVID-19 polymerase.

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Garmay, Y. P., Rubel, A. A., Egorov, V. V.. 2022-06-28. Peptide from NSP7 is able to form amyloid-like fibrils: artifact or challenge to drug design?. https://doi.org/10.1101/2022.06.28.497929

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