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bioRxiv · 10.1101/2022.05.26.493655

ZNF692 organizes a hub for ribosome maturation enhancing translation in rapidly proliferating cells

Conacci-Sorrell, M.
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Abstract

Rapidly proliferating cells produce more ribosomes to translate sufficient proteins for cell growth. One of the first and rate limiting steps in translation initiation is the interaction of the small ribosomal subunit with mRNAs. Therefore, effective small ribosomal subunit biogenesis is critical for translation initiation efficiency. Here we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small 40S ribosome. ZNF692 forms a complex with rRNA, the 90S processome and the nucleolar exosome in the granular component of the nucleolus creating a hub specialized in the final steps of 18S processing and small ribosomal subunit maturation. Cancer cells are more reliant on ZNF692 for increased translation than normal cells. We propose that MYC increases translation efficiency by promoting the expression of ZNF692, adjusting the translation rate to the increase in mRNA transcription induced by MYC.

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Conacci-Sorrell, M.. 2022-05-26. ZNF692 organizes a hub for ribosome maturation enhancing translation in rapidly proliferating cells. https://doi.org/10.1101/2022.05.26.493655

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