The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution

Nair, S.; Barrett, A.; Li, D.; Raney, B. J.; Lee, B. T.; Kerpedjiev, P.; Ramalingam, V.; Pampari, A.; Lekschas, F.; Wang, T.; Haeussler, M.; Kundaje, A.

doi:10.1101/2022.05.26.493621

bioRxiv · 10.1101/2022.05.26.493621

The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution

Nair, S.·Barrett, A.·Li, D.·Raney, B. J.·Lee, B. T.·Kerpedjiev, P.·Ramalingam, V.·Pampari, A.·Lekschas, F.·Wang, T.·Haeussler, M.·Kundaje, A.

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Abstract

We introduce the dynseq genome browser track, which displays DNA nucleotide characters scaled by user-specified, base-resolution scores provided in the BigWig file format. The dynseq track enables visualization of context-specific, informative genomic sequence features. We demonstrate its utility in three popular genome browsers for interpreting cis-regulatory sequence syntax and regulatory variant interpretation by visualizing nucleotide importance scores derived from machine learning models of regulatory DNA trained on protein-DNA binding and chromatin accessibility experiments.

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Nair, S., Barrett, A., Li, D., Raney, B. J., Lee, B. T., Kerpedjiev, P., Ramalingam, V., Pampari, A., Lekschas, F., Wang, T., Haeussler, M., Kundaje, A.. 2022-05-28. The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution. https://doi.org/10.1101/2022.05.26.493621

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