Improved antibody-specific epitope prediction using AlphaFold and AbAdapt

Xu, Z.; Davila, A.; Wiamowski, J.; Teraguchi, S.; Standley, D. M.

doi:10.1101/2022.05.21.492907

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bioRxiv · 10.1101/2022.05.21.492907

Improved antibody-specific epitope prediction using AlphaFold and AbAdapt

Xu, Z.·Davila, A.·Wiamowski, J.·Teraguchi, S.·Standley, D. M.

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Abstract

Antibodies recognize their cognate antigens with high affinity and specificity, but the prediction of binding sites on the antigen (epitope) corresponding to a specific antibody remains a challenging problem. To address this problem, we developed AbAdapt, a pipeline that integrates antibody and antigen structural modeling with rigid docking in order to derive antibody-antigen specific features for epitope prediction. In this study, we assess the impact of integrating the state-of-the-art protein modeling method AlphaFold with the AbAdapt pipeline and demonstrate significant improvement in the prediction of antibody-specific epitope residues.

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Xu, Z., Davila, A., Wiamowski, J., Teraguchi, S., Standley, D. M.. 2022-05-22. Improved antibody-specific epitope prediction using AlphaFold and AbAdapt. https://doi.org/10.1101/2022.05.21.492907

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