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bioRxiv · 10.1101/2022.05.17.492357

Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

Abstract

Transient dark exposure, typically 7-10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vison in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced changes in cellular signaling pathways result in the re-engagement of juvenile-like plasticity in the adult such that previously deprived inputs can gain cortical territory. It is possible that dark exposure itself degrades visual responses, and this could place constraints on the optimal duration of dark exposure treatment. To determine whether eight days of dark exposure has a lasting negative impact on responses to classic grating stimuli, neural activity was recorded before and after dark exposure in awake head-fixed mice using 2-photon calcium imaging. Neural discriminability, assessed using classifiers, was transiently reduced following dark exposure; a decrease in response reliability across a broad range of spatial frequencies accounted for the disruption. Both discriminability and reliability recovered. Fixed classifiers were used to demonstrated that stimulus representation rebounded to the original, pre-deprivation state, thus DE did not appear to have a lasting negative impact on visual processing. Unexpectedly, we found that dark exposure significantly stabilized orientation preference and signal correlation. Our results reveal that natural vision exerts a disrupting influence on the stability of stimulus preference for classic grating stimuli, and at the same time improves neural discriminability for both low and high spatial frequency stimuli.

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BibTeXRIS

Jeon, B. B., Fuchs, T., Chase, S. M., Kuhlman, S. J.. 2022-05-18. Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex. https://doi.org/10.1101/2022.05.17.492357

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