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bioRxiv · 10.1101/2022.05.10.490642

Mechanochemical rules for membrane-reshaping composite filaments

Meadowcroft, B.·Palaia, I.·Pfitzner, A.-K.·Roux, A.·Baum, B.·Saric, A.
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Abstract

The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how ESCRT-III polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein-membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodelling and show this mechanism is efficient because sequential polymer assembly lowers the energetic barrier for membrane deformation.

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Meadowcroft, B., Palaia, I., Pfitzner, A.-K., Roux, A., Baum, B., Saric, A.. 2022-05-10. Mechanochemical rules for membrane-reshaping composite filaments. https://doi.org/10.1101/2022.05.10.490642

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