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bioRxiv · 10.1101/2022.04.12.488026

Control and coding of pupil size by hypothalamic orexin neurons

Grujic, N.·Tesmer, A.·Bracey, E. F.·Peleg-Raibstein, D.·Burdakov, D.
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Abstract

Brain orexin (hypocretin) neurons are implicated in sleep-wake switching and reward-seeking, but their roles in rapid arousal dynamics and reward perception remain unclear. Here, cellspecific stimulation, deletion, and in vivo recordings revealed strong correlative and causal links between pupil dilation - a quantitative arousal marker - and orexin cell activity. Coding of arousal and reward was distributed across orexin cells, indicating that they specialize in rapid, multiplexed communication of momentary arousal and reward states.

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Grujic, N., Tesmer, A., Bracey, E. F., Peleg-Raibstein, D., Burdakov, D.. 2022-04-13. Control and coding of pupil size by hypothalamic orexin neurons. https://doi.org/10.1101/2022.04.12.488026

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