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bioRxiv · 10.1101/2022.04.06.487231

A descending interneuron with depolarized resting membrane potential controls C. elegans motor states

Abstract

Continuity of behaviors requires animals to make smooth transitions between successive and mutually exclusive behavioral states. Neural principles that govern these transitions are not well understood. C. elegans spontaneously switch between two opposite motor states, forward and backward movement, a phenomenon long thought to reflect the reciprocal inhibition between two interneurons that separately gate the forward and backward motor circuits, AVB and AVA. Combining experimental data and mathematical modeling, we report that spontaneous forward and backward locomotion and their corresponding motor circuits are not separately controlled. AVA and AVB are neither functionally equivalent nor strictly reciprocally inhibitory. Instead, while AVA phasically inhibits the forward promoting interneuron AVB at a fast timescale, it maintains a tonic, extrasynaptic excitation on AVB over the longer timescale. AVAs depolarized spontaneous membrane potential is necessary for this tonic excitation. We propose a new, master neuron model for locomotion. AVA, with tonic and phasic activity of opposite polarities on different time scales, acts as a master neuron to break the symmetry between the underlying forward and backward motor circuits. This offers a parsimonious solution for sustained locomotion consisted of mutually exclusive motor states. TeaserA tonically active C. elegans premotor interneuron functions as the master neuron that underlies continuous modulation of forward and backward movement to ensure smooth transitions between the two opposing motor states.

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BibTeXRIS

Meng, J., Ahamed, T., Yu, B., Hung, W., El Mouridi, S., Leclercq-Blondel, A., Gendrel, M., Wang, Z., Chen, L., Wen, Q., Boulin, T., Gao, S., Zhen, M.. 2022-04-09. A descending interneuron with depolarized resting membrane potential controls C. elegans motor states. https://doi.org/10.1101/2022.04.06.487231

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