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bioRxiv · 10.1101/2022.03.26.485076

The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein

Struwe, M. A.·Clement, B.·Scheidig, A. J.
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Abstract

Recent genome-wide association studies (GWAS) have shown a common variant of the human mARC1 protein to be associated with liver disease. Herein, we present the crystal structure of this mARC1 p.Ala165Thr at near-atomic resolution. No relevant differences between the structure of wild type mARC1 and the variant protein are detected.

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Struwe, M. A., Clement, B., Scheidig, A. J.. 2022-03-28. The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein. https://doi.org/10.1101/2022.03.26.485076

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