Type I interferons govern Zika virus resistance of human macrophages and microglia

Hanrath, A. T.; Hatton, C. F.; Gothe, F.; Browne, C.; Vowles, J.; Leary, P.; Cockell, S. J.; Cowley, S. A.; James, W. S.; Hambleton, S.; Duncan, C. J. A.

doi:10.1101/2022.03.09.483671

bioRxiv · 10.1101/2022.03.09.483671

Type I interferons govern Zika virus resistance of human macrophages and microglia

Hanrath, A. T.·Hatton, C. F.·Gothe, F.·Browne, C.·Vowles, J.·Leary, P.·Cockell, S. J.·Cowley, S. A.·James, W. S.·Hambleton, S.·Duncan, C. J. A.

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Abstract

The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Therapeutic manipulation of the IFN-I system may bring clinical benefit in ZIKV.

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Hanrath, A. T., Hatton, C. F., Gothe, F., Browne, C., Vowles, J., Leary, P., Cockell, S. J., Cowley, S. A., James, W. S., Hambleton, S., Duncan, C. J. A.. 2022-03-11. Type I interferons govern Zika virus resistance of human macrophages and microglia. https://doi.org/10.1101/2022.03.09.483671

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