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bioRxiv · 10.1101/2022.03.04.483057

An updated map of GRCh38 linkage disequilibrium blocks based on European ancestry data

MacDonald, J.·Harrison, T.·Bammler, T.·Mancuso, N.·Lindstroem, S.
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Abstract

A map of approximately independent linkage disequilibrium (LD) blocks has many uses in statistical genetics. Current publicly available LD block maps are based on sparse recombination maps and are only available for GRCh37 (hg19) and prior genome assemblies. We generated LD blocks in GRCh38 coordinates for African (AFR), East Asian (EAS), European (EUR) and South Asian (SAS) ancestry populations. These new maps consist of 1,143 (EAS) - 1,604 (AFR) independent LD blocks across the 22 autosomal chromosomes and can be accessed at https://github.com/jmacdon/LDblocks_GRCh38.

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MacDonald, J., Harrison, T., Bammler, T., Mancuso, N., Lindstroem, S.. 2022-03-07. An updated map of GRCh38 linkage disequilibrium blocks based on European ancestry data. https://doi.org/10.1101/2022.03.04.483057

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