A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

Yuan, Y.; Gao, X.; Ni, F.; Xie, W.; Fu, W.; Zhang, G.; Hu, H.; Li, Y.; Hu, Q.; Huang, C.; Liu, B.; Liu, Y.; Shen, Q.; Liang, M.

doi:10.1101/2022.02.21.481247

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bioRxiv · 10.1101/2022.02.21.481247

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

Yuan, Y.·Gao, X.·Ni, F.·Xie, W.·Fu, W.·Zhang, G.·Hu, H.·Li, Y.·Hu, Q.·Huang, C.·Liu, B.·Liu, Y.·Shen, Q.·Liang, M.

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Abstract

The coronavirus SARS-CoV-2 has a severe impact on global public health, and the emerging variants threaten the efficacy of the circulating vaccines. Here, we report that a single vaccination with a non-replicating chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant (JS1-delta) elicits potent humoral, cellular and mucosal immunity in mice. Additionally, a single intranasal administration of JS1-delta provides effective protection against the Delta (B.1.617.2) variant challenge in mice. This study indicates that chimpanzee adenovirus type 3 (ChAd3) derived vector represents a promising platform for antiviral vaccine development against respiratory infections and JS1-delta is worth further investigation in human clinical trials. HighlightsO_LIA new chimpanzee adenoviral vaccine against the SARS-CoV-2 Delta variant was developed. C_LIO_LIThe vaccine elicited potent humoral, cellular and mucosal immunity in mice. C_LIO_LIThe vaccine protected mice from the Delta variant challenge. C_LI

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Yuan, Y., Gao, X., Ni, F., Xie, W., Fu, W., Zhang, G., Hu, H., Li, Y., Hu, Q., Huang, C., Liu, B., Liu, Y., Shen, Q., Liang, M.. 2022-02-22. A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development. https://doi.org/10.1101/2022.02.21.481247

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