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bioRxiv · 10.1101/2022.02.18.480896

Alternative c-MYC mRNA transcripts as an additional tool for c-Myc2 and c-MycS production in BL60 tumors.

IBRAHIM, D.·FAUMONT, N.·TROUTAUD, D.·FEUILLARD, J.·DIAB-ASSAF, M.·OULMOUDEN, A.
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Abstract

While studying c-Myc protein expression in several Burkitt lymphoma cell lines and in lymph nodes from a mouse model bearing a translocated c-MYC gene from the human BL line IARC-BL60, we surprisingly discovered a complex electrophoretic profile. Indeed, the BL60 cell line carrying the t(8;22) c-MYC translocation exhibits a simple pattern, with a single c-Myc2 isoform. Analysis of the c-MYC transcripts expressed by tumor lymph nodes in the mouse{lambda} c-MYC (Avy/a) showed for the first time five transcripts associated with t(8;22) c-MYC translocation. The five transcripts were correlated with the production of c-Myc2 and c-MycS, and loss of c-Myc1. The contribution of these transcripts to the oncogenic activation of the t(8;22) c-MYC is discussed.

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IBRAHIM, D., FAUMONT, N., TROUTAUD, D., FEUILLARD, J., DIAB-ASSAF, M., OULMOUDEN, A.. 2022-02-19. Alternative c-MYC mRNA transcripts as an additional tool for c-Myc2 and c-MycS production in BL60 tumors.. https://doi.org/10.1101/2022.02.18.480896

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