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bioRxiv · 10.1101/2022.02.09.479810

Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes

Sasaki, E.·Gunis, J.·Reichardt-Gomez, I.·Nizhynska, V.·Nordborg, M.
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Abstract

Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture -- once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization.

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Sasaki, E., Gunis, J., Reichardt-Gomez, I., Nizhynska, V., Nordborg, M.. 2022-02-10. Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes. https://doi.org/10.1101/2022.02.09.479810

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