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bioRxiv · 10.1101/2022.02.01.478558

Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification

Nam, A. S.·Vakoc, B. J.·Braaf, B.
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Abstract

To our knowledge, all existing optical coherence tomography approaches for quantifying blood flow, whether Doppler-based or decorrelation-based, analyze light that is back-scattered by moving red blood cells (RBCs). This work investigates the potential advantages of basing these measurements on light that is forward-scattered by RBCs, i.e., by looking at the signals back-scattered from below the vessel. We show experimentally that this results in a flowmetry measure that is insensitive to vessel orientation for vessels that are approximately orthogonal to the imaging beam. We further provide proof-of-principle demonstrations that DFS can be used to measure flow in human retinal and choroidal vessels.

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Nam, A. S., Vakoc, B. J., Braaf, B.. 2022-02-04. Using the Dynamic Forward Scattering Signal for Optical Coherence Tomography based Blood Flow Quantification. https://doi.org/10.1101/2022.02.01.478558

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